ISSN 1662-4009 (online)

ey0015.12-3 | New Mechanism | ESPEYB15

12.3 The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity

C Cropano , N Santoro , L Groop , C Dalla Man , C Cobelli , A Galderisi , R Kursawe , B Pierpont , M Goffredo , S Caprio

To read the full abstract: Diabetes Care 2017;40:1082-1089Transcription factor 7-like 2 (TCF7L2) is a protein encoded by the TCF7L2 gene located on chromosome 10q25.2-q25.3 and is involved in the development of a wide variety of cell lineages and organs. The rs7903146 <a href="https://en.wikipedia.org...